Name:Sodium stibogluconate
Synonyms:SSG, Stibogluconate sodium, Stibogluconate trisodium nonahydrate, Lenocta, VQD-001
CAS Number:16037-91-5
Formula:C12H35Na3O26Sb2
M.w.:907.88
DMSO (mg/mL)Max Solubility:<1
DMSO (mM)Max Solubility:N/A
Form:Sodium
SMILES:O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].OCC(O)C1O[Sb]2(O)(OC1C(O2)C([O-])=O)O[Sb]34([O-])OC(C(O)CO)C(O3)C(O4)C([O-])=O
ALogP:-8.931
Target:phosphatase
Pathway:Metabolism
Information:Sodium stibogluconate (SSG, Stibogluconate trisodium nonahydrate, Lenocta, VQD-001), a pentavalent antimony derivative, is a potent and selective inhibitor of protein tyrosine phosphatase (PTPase). Sodium stibogluconate inhibits 99% of Src homology 2 domain-containing phosphatase 1 (SHP-1) activity at 10 μg/ml and similar degrees of inhibition of SHP-2 and PTP1B requires 100 μg/ml. Sodium stibogluconate is a drug used in treatment of leishmaniasis.
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