Name:Rosiglitazone (BRL 49653)
Synonyms:BRL 49653
CAS Number:122320-73-4
Formula:C18H19N3O3S
M.w.:357.43
DMSO (mg/mL)Max Solubility:71
DMSO (mM)Max Solubility:198.64
Form:Free Base
SMILES:CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C3=CC=CC=N3
ALogP:3.268
Target:Autophagy,Ferroptosis,PPAR,TRP Channel
Pathway:Metabolism
Information:Rosiglitazone (BRL 49653) is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. Rosiglitazone is a pure ligand of PPAR-gamma, and has no PPAR-alpha-binding action. Rosiglitazone modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.
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