Name:Capmatinib (INCB28060)
Synonyms:INC280, NVP-INC280
CAS Number:1029712-80-8
Formula:C23H17FN6O
M.w.:412.42
DMSO (mg/mL)Max Solubility:2
DMSO (mM)Max Solubility:4.85
Form:Free Base
SMILES:CNC(=O)C1=CC=C(C=C1F)C2=N[N]3C(=CN=C3N=C2)CC4=CC=C5N=CC=CC5=C4
ALogP:3.246
Target:Apoptosis related,c-Met,Wnt/beta-catenin
Pathway:Protein Tyrosine Kinase
Information:Capmatinib (INCB28060, INC280, NVP-INC280) is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM in a cell-free assay, inactive against RONβ, as well as EGFR and HER-3. Capmatinib (INCB28060) inhibits Wnt/β-catenin and EMT signaling pathways and induces apoptosis in diffuse gastric cancer positive for c-MET amplification. Phase 1.
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