Name:Auranofin
Synonyms:Ridaura, SKF39162
CAS Number:34031-32-8
Formula:C20H34AuO9PS
M.w.:678.48
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:147.39
Form:Free Base
SMILES:CCP(|[Au]SC1OC(COC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O)(CC)CC
ALogP:1.407
Target:Bacterial,Thioredoxin Reductase
Pathway:Microbiology
Information:Auranofin (Ridaura, SKF-39162) is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.
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