Name:Ixazomib Citrate (MLN9708)
Synonyms:Ninlaro
CAS Number:1239908-20-3
Formula:C20H23BCl2N2O9
M.w.:517.12
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:193.38
Form:Free Base
SMILES:CC(C)CC(NC(=O)CNC(=O)C1=C(Cl)C=CC(=C1)Cl)B2OC(=O)C(CC(O)=O)(CC(O)=O)O2
ALogP:3.497
Target:Proteasome
Pathway:Proteases
Information:Ixazomib citrate (MLN9708, Ninlaro) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ixazomib (MLN2238) also inhibits caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50 of 31 nM and 3500 nM, respectively.
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