Name:Ropsacitinib (PF-06826647)
Synonyms:Tyk2-IN-8, compound 10
CAS Number:2127109-84-4
Formula:C20H17N9
M.w.:383.41
DMSO (mg/mL)Max Solubility:77
DMSO (mM)Max Solubility:200.83
Form:Free base
SMILES:C[N]1C=C(C=N1)C2=C[N]3N=CC=C3C(=N2)C4=C[N](N=C4)C5(CC#N)CC(C5)C#N
ALogP:1.315
Target:JAK
Pathway:JAK/STAT
Information:Ropsacitinib (PF-06826647, Tyk2-IN-8, compound 10) is a selective and orally administered inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 17 nM for binding to TYK2 catalytically active JH1 domain. PF-06826647 (Tyk2-IN-8, compound 10) also inhibits JAK1 and JAK2 with IC50 of 383 nM and 74 nM, respectively. PF-06826647 (Tyk2-IN-8, compound 10) is used in the treatment of psoriasis (PSO).
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