Name:Rolapitant
Synonyms:SCH-619734
CAS Number:552292-08-7
Formula:C25H26F6N2O2
M.w.:500.48
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:199.81
Form:NK1 receptor antagonists
SMILES:CC(OCC1(CCC2(CCC(=O)N2)CN1)C3=CC=CC=C3)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F
ALogP:4.761
Target:Neurokinin Receptor
Pathway:Neuronal Signaling
Information:Rolapitant (SCH-619734) is a selective and competitive antagonist of human substance P/NK1 receptors with antiemetic activity. It has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold, as well as preferential affinity for human, guinea pig, gerbil and monkey NK1 receptors over rat, mouse and rabbit.
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