Name:Harmine hydrochloride
Synonyms:Telepathine hydrochloride
CAS Number:343-27-1
Formula:C13H12N2O.HCl
M.w.:248.71
DMSO (mg/mL)Max Solubility:21
DMSO (mM)Max Solubility:84.44
Form:hydrochloride
SMILES:Cl.COC1=CC2=C(C=C1)C3=CC=NC(=C3[NH]2)C
ALogP:2.82
Target:5-HT Receptor,ADC Cytotoxin,DYRK,MAO
Pathway:Cell Cycle
Information:Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.
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