Name:PF-06840003
Synonyms:EOS200271
CAS Number:198474-05-4
Formula:C12H9FN2O2
M.w.:232.21
DMSO (mg/mL)Max Solubility:46
DMSO (mM)Max Solubility:198.1
Form:free base
SMILES:FC1=CC=C2[NH]C=C(C3CC(=O)NC3=O)C2=C1
ALogP:1.201
Target:IDO/TDO
Pathway:Metabolism
Information:PF-06840003 (EOS200271) is a highly selective orally bioavailable IDO-1 inhibitor. Although it has moderate hIDO1 enzyme inhibition (IC50 0.41 μM), it is a highly efficient compound (LE 0.53, LipE 5.1), driven by its tight packing within the enzyme, as well as the high density of hydrogen bonds it forms with hIDO-1 despite its small size.
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