Name:Glycerol phenylbutyrate
Synonyms:GT4P, HPN-100M, Ravicti
CAS Number:611168-24-2
Formula:C33H38O6
M.w.:530.65
DMSO (mg/mL)Max Solubility:The physical form of the compound is liquid, which can be dissolved in any proportion.
DMSO (mM)Max Solubility:0
Form:Free Base
SMILES:O=C(CCCC1=CC=CC=C1)OCC(COC(=O)CCCC2=CC=CC=C2)OC(=O)CCCC3=CC=CC=C3
ALogP:7.563
Target:Sigma Receptor
Pathway:GPCR & G Protein
Information:Glycerol phenylbutyrate (GT4P, HPN-100M, Ravicti) is a nitrogen-binding agent and acts as a sigma-2 (σ2) receptor ligand with a pKi of 8.02. Glycerol phenylbutyrate is a prodrug in which phenylbutyrate (PBA) is released from the glycerol backbone by lipases in the gastrointestinal tract.
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