Name:JTE-607 Dihydrochloride
Synonyms:N/A
CAS Number:188791-09-5
Formula:C25H31Cl2N3O5.2ClH
M.w.:597.36
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:167.4
Form:Dihydrochloride
SMILES:Cl.Cl.CCOC(=O)C(CC1=CC=CC=C1)NC(=O)C2=CC(=C(OCCN3CCN(C)CC3)C(=C2O)Cl)Cl
ALogP:5.06
Target:Interleukins,TNF-alpha
Pathway:Apoptosis
Information:JTE-607 Dihydrochloride is a prodrug compound that is converted to an active form by ester hydrolysis. JTE-607 is a multiple cytokine production inhibitor that targets CPSF3 and inhibits pre-mRNA processing. JTE-607 inhibits tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50 values of 11 nM, 5.9 nM, 8.8 nM, 7.3 nM and 9.1 nM, respectively.
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