Name:Chiauranib
Synonyms:CS2164
CAS Number:1256349-48-0
Formula:C27H21N3O3
M.w.:435.5
DMSO (mg/mL)Max Solubility:87
DMSO (mM)Max Solubility:199.77
Form:Free base
SMILES:COC1=CC2=C(C=C1)C(=CC=N2)OC3=CC4=C(C=C3)C(=CC=C4)C(=O)NC5=C(N)C=CC=C5
ALogP:4.506
Target:Aurora Kinase,c-Kit,CSF-1R,PDGFR,VEGFR
Pathway:Protein Tyrosine Kinase
Information:Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.
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