Name:Raltegravir (MK-0518)
Synonyms:MK-0518
CAS Number:518048-05-0
Formula:C20H21FN6O5
M.w.:444.42
DMSO (mg/mL)Max Solubility:88
DMSO (mM)Max Solubility:198.01
Form:free base
SMILES:CN1C(=O)C(=C(N=C1C(C)(C)NC(=O)C2=NN=C(C)O2)C(=O)NCC3=CC=C(F)C=C3)O
ALogP:-0.291
Target:Integrase
Pathway:Microbiology
Information:Raltegravir (MK-0518) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM in cell-free assays, respectively. It shows greater than 1000-fold selectivity for HIV-1 IN over several related Mg2+-dependent enzyme such as HCV polymerase, HIV reverse transcriptase, HIV RNaseH and human α-, β-, γ-polymerases.
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